IFIT2 Antikörper (AA 150-370)

Produktnummer ABIN5027290

Der Kaninchen Polyklonal anti-IFIT2 Antikörper wird verwendet zum Nachweis von IFIT2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für IFIT2 Antikörper (AA 150-370) (ABIN5027290)

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFIT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IFIT2 Antikörper

Bindungsspezifität: AA 150-370

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant IFIT2 protein (amino acids 150-370) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu IFIT2

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Andere Bezeichnung: IFIT2

Hintergrund: Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is one of four related human (ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, ISG58/IFIT5) and three related mouse proteins (Ifit1, Ifit2, Ifit3) characterized by tetratricopeptide motifs. IFIT2 interacts with eukaryotic initiation factor 3 (eIF3)e and eIF3c to inhibit translation. IFIT2 interacts with some AU-rich RNA regions, which seems to be associated with antiviral activity. IFIT2 possesses antiviral activity against corona virus and West Nile virus by acting on the capped viral mRNA and protects from lethal vesicular stomatitis virus neuropathogenesis. Besides the antiviral activity, IFIT2 expression was associated with induction of apoptosis. IFIT2 may alter proinflammatory cytokine response and therefore be involved in the development of septic shock.

Molekulargewicht: 54 kDa

Gen-ID: 3433

UniProt: P09913