FURIN Antikörper (AA 602-791)

Produktnummer ABIN5027210

Der Kaninchen Polyklonal anti-FURIN Antikörper (ABIN5027210) detektiert spezifisch FURIN in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für FURIN Antikörper (AA 602-791) (ABIN5027210)

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FURIN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FURIN Antikörper

Bindungsspezifität: AA 602-791

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant Furin protein (amino acids 602-791) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Andere Bezeichnung: Furin

Hintergrund: Furin is a member of the PCs family (Pro-Hormone/Pro-Protein Convertase) of subtilisin-like endoproteinases. Furin along with PCs are intensively investigated as pharmacological targets for the treatment of many diseases, e.g., atherosclerosis, hypercholesterolaemia, and cancer, as well as viral and bacterial infections. Furin has been implicated in processing the Env (Envelope) proteins of human endogenous retroviruses, syncytins, the only possible fusogens known to be involved in placenta syncytialization, and therefore may participate in syncytin-mediated cell fusion in cells of both trophoblast and non-trophoblast lineages. Furin catalyzes proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive. Furin is highly expressed in EVTs (Extravillous CTBs) and that furin function is required for trophoblast cell invasion into the maternal endometrium.

Molekulargewicht: 97 kDa

Gen-ID: 5045

UniProt: P09958

Pathways: Notch Signalweg, Neurotrophin Signalübertragung