FLT1 Antikörper (AA 102-321)

Produktnummer ABIN5027202

Produktdetails anti-FLT1 Antikörper

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Bindungsspezifität: AA 102-321

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FLT1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant FLT1 protein (amino acids 102-321) was used as the immunogen for this antibody.

Klon: ABM4A56

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: IHC: 5-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu FLT1

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Andere Bezeichnung: FLT1 (FLT1 Produkte)

Synonyme: FLT antikoerper, FLT-1 antikoerper, VEGFR-1 antikoerper, VEGFR1 antikoerper, FLT1 antikoerper, flt1b antikoerper, sFlt1 antikoerper, AI323757 antikoerper, Flt-1 antikoerper, fms related tyrosine kinase 1 antikoerper, FMS-related tyrosine kinase 1 antikoerper, vascular endothelial growth factor receptor 1 antikoerper, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antikoerper, FMS-like tyrosine kinase 1 antikoerper, vascular endothelial growth factor receptor-1 antikoerper, FLT1 antikoerper, Flt1 antikoerper, CpipJ_CPIJ012087 antikoerper, flt1 antikoerper, FLT-1 antikoerper

Hintergrund: FLT-1 (fms-related tyrosine kinase 1) is an endogenous inhibitor of vascular endothelial growth factor, which is involved in cardiovascular remodeling and atherosclerosis development. It potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). FLT-1 is expressed on tumor cells and is implicated in tumor growth and progression. It is overexpressed in primary tumors and nodal metastasis. FLT-1 regulates monocyte migration, recruits endothelial cell progenitors, increases the adhesive properties of natural killer cells and induces growth factors. It is observed in many diseases with endothelial dysfunction, including pre-eclampsia and diabetic retinopathy, but whether it contributes to endothelial injury in IgAN requires further exploration.

Gen-ID: 2321

UniProt: P17948

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals