CD3 epsilon Antikörper (AA 2-203)

Produktnummer ABIN5027093

Dieses Anti-CD3 epsilon-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD3 epsilon in WB und IHC. Geeignet für Human.

Kurzübersicht für CD3 epsilon Antikörper (AA 2-203) (ABIN5027093)

Target: CD3 epsilon (CD3E)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD3 epsilon Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: ABM45B3

Produktdetails anti-CD3 epsilon Antikörper

Bindungsspezifität: AA 2-203

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant CD3e protein (amino acids 2-203) was used as the immunogen for this antibody.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 0.5-1 μg/mL, IHC: 5-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu CD3 epsilon

Target: CD3 epsilon (CD3E)

Andere Bezeichnung: CD3e

Hintergrund: CD3e (CD3-epsilon), together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The gene for CD3e have been mapped to band q23 of chromosome 11 in humans and consisted of nine exons. Three exons, encoding the junction of leader peptide and mature protein, are extremely small. The CD3e cytoplasmic tail, highly conserved, can be tentatively subdivided into three regions, the N-terminal region contains a basic amino acid cluster, the central region contains a proline-rich sequence, and the C-terminal region contains the ITAM . Among the CD3 subunits, CD3e is the most likely candidate for performing a critical role in the TCR signaling response. CD3e is represented twice in the TCR complex, serving as a component of both the gamma/epsilon and delta/epsilon dimers. In addition, after TCR cross-linking, CD3e and zeta are the predominant tyrosine-phosphorylated TCR subunits.

Molekulargewicht: 22 kDa

Gen-ID: 916

UniProt: P07766

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway