CADM1 Antikörper (AA 50-250)

Produktnummer ABIN5027069

Dieses Anti-CADM1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CADM1 in WB. Geeignet für Human.

Kurzübersicht für CADM1 Antikörper (AA 50-250) (ABIN5027069)

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CADM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CADM1 Antikörper

Bindungsspezifität: AA 50-250

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant CADM1 protein (amino acids 50-250) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu CADM1

Target: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Andere Bezeichnung: CADM1

Hintergrund: Cell Adhesion Molecule 1 (CADM1) encodes a multifunctional immunoglobulin-like cell adhesion molecule whose cytoplasmic domain contains a type II PSD95/Dlg/ZO-1 (PDZ)-binding motif (BM) for associating with other intracellular proteins. CADM1 lacks expression in T lymphocytes of healthy individuals and is overexpressed in adult T-cell leukemia-lymphoma (ATL) cells. CADM1 generates a membrane-associated C-terminal fragment, AlphaCTF, through A disintegrin- and metalloprotease-10-mediated ectodomain shedding, subsequently releasing the intracellular domain (ICD) through gamma-secretase-mediated intramembrane shedding of alphaCTF. alphaCTF localizes to mitochondria and induces apoptosis in lung epithelial cells. In women with multiple cervical biopsies, CADM1/MAL methylation increases with severity of the lesion and is lesion-specific. CADM1/MAL methylation status in cervical scrapes appears to be representative of the worst underlying lesion, particularly for CIN3 and cervical cancer.

Molekulargewicht: 42 kDa

Gen-ID: 23705

UniProt: Q9BY67

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation