BCL6 Antikörper (AA 200-401)

Produktnummer ABIN5027051

Der Maus Monoklonal anti-BCL6 Antikörper (Klon ABM44G9) (ABIN5027051) detektiert spezifisch BCL6 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für BCL6 Antikörper (AA 200-401) (ABIN5027051)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCL6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: ABM44G9

Produktdetails anti-BCL6 Antikörper

Bindungsspezifität: AA 200-401

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant BCL-6 protein (amino acids 200-401) was used as the immunogen for this antibody.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Andere Bezeichnung: BCL-6

Hintergrund: BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.

Molekulargewicht: 72 kDa

Gen-ID: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus