14-3-3 theta Antikörper (AA 20-225)

Produktnummer ABIN5027003

Produktdetails anti-14-3-3 theta Antikörper

Target: 14-3-3 theta (YWHAQ)

Bindungsspezifität: AA 20-225

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 14-3-3 theta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant 14-3-3 protein (amino acids 20-225) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu 14-3-3 theta

Target: 14-3-3 theta (YWHAQ)

Andere Bezeichnung: YWHAQ (YWHAQ Produkte)

Synonyme: 14-3-3 antikoerper, 14-3-3t antikoerper, 1c5 antikoerper, hs1 antikoerper, 1C5 antikoerper, HS1 antikoerper, 2700028P07Rik antikoerper, AA409740 antikoerper, AU021156 antikoerper, R74690 antikoerper, ywhaq antikoerper, ywhaq2 antikoerper, wu:fa91b01 antikoerper, wu:fb02e12 antikoerper, wu:fb36f06 antikoerper, wu:fk86h02 antikoerper, ywhaq1 antikoerper, ywhaz antikoerper, zgc:55499 antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta S homeolog antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a antikoerper, 14-3-3 protein theta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b antikoerper, YWHAQ antikoerper, ywhaq antikoerper, Ywhaq antikoerper, ywhaq.S antikoerper, ywhaqa antikoerper, ywhaqb antikoerper

Hintergrund: YWHAQ, also known as 14-3-3 tau (14-3-3tau) is a a phosphoserine-binding protein and a member of the 14-3-3 family of proteins. The 14-3-3 family members are dimeric phosphoserine/ phosphothreonine-binding proteins, which are involved in a very diverse spectrum of signaling pathways. YWHAQ plays a critical role in the regulation of E2F1 stability. It binds to Ser31-phosphorylated E2F1 and inhibits the ubiquitination of E2F1 during DNA damage. The binding of YWHAQ to E2F1 interferes with the function of an E31 ligase and therefore inhibits the ubiquitination and degradation of E2F1. This interaction is required for the expression and induction of several E2F1 apoptotic target genes as well as apoptosis during DNA damage.

Molekulargewicht: 29 kDa

Gen-ID: 10971

UniProt: P27348

Pathways: Apoptose, Myometrial Relaxation and Contraction