14-3-3 theta Antikörper (AA 20-225)

Produktnummer ABIN5027003

Dieses Anti-14-3-3 theta-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von 14-3-3 theta in WB. Geeignet für Human.

Kurzübersicht für 14-3-3 theta Antikörper (AA 20-225) (ABIN5027003)

Target: 14-3-3 theta (YWHAQ)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 14-3-3 theta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-14-3-3 theta Antikörper

Bindungsspezifität: AA 20-225

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant 14-3-3 protein (amino acids 20-225) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu 14-3-3 theta

Target: 14-3-3 theta (YWHAQ)

Andere Bezeichnung: YWHAQ

Hintergrund: YWHAQ, also known as 14-3-3 tau (14-3-3tau) is a a phosphoserine-binding protein and a member of the 14-3-3 family of proteins. The 14-3-3 family members are dimeric phosphoserine/ phosphothreonine-binding proteins, which are involved in a very diverse spectrum of signaling pathways. YWHAQ plays a critical role in the regulation of E2F1 stability. It binds to Ser31-phosphorylated E2F1 and inhibits the ubiquitination of E2F1 during DNA damage. The binding of YWHAQ to E2F1 interferes with the function of an E31 ligase and therefore inhibits the ubiquitination and degradation of E2F1. This interaction is required for the expression and induction of several E2F1 apoptotic target genes as well as apoptosis during DNA damage.

Molekulargewicht: 29 kDa

Gen-ID: 10971

UniProt: P27348

Pathways: Apoptose, Myometrial Relaxation and Contraction