CLEC4E Antikörper

Produktnummer ABIN5026978

Der Maus Monoklonal anti-CLEC4E Antikörper wird verwendet zum Nachweis von CLEC4E in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für CLEC4E Antikörper (ABIN5026978)

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CLEC4E Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: ABM42C6

Produktdetails anti-CLEC4E Antikörper

Aufreinigung: Protein G Chromatography

Immunogen: A full length human CLEC4E protein was used as the immunogen for this antibody.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu CLEC4E

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Andere Bezeichnung: CLEC4E

Hintergrund: CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.

Molekulargewicht: 25 kDa

Gen-ID: 26253

UniProt: Q9ULY5