TNIK Antikörper (pSer764) (AbBy Fluor® 750)
Kurzübersicht für TNIK Antikörper (pSer764) (AbBy Fluor® 750) (ABIN5011786)
Target
Alle TNIK Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pSer764
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Spezifität
- Phosphorylation site corresponds to Ser735 in mouse
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Kreuzreaktivität
- Maus, Ratte
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Homologie
- Human,Dog,Cow,Pig,Horse
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic phosphopeptide derived from human TNIK around the phosphorylation site of Ser764
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Isotyp
- IgG
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Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Haltbarkeit
- 12 months
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- TNIK (TRAF2 and NCK Interacting Kinase (TNIK))
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Andere Bezeichnung
- TNIK
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Hintergrund
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Synonyms: TRAF2 and NCK-interacting protein kinase, TNIK, KIAA0551
Background: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
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Gen-ID
- 23043
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UniProt
- Q9UKE5
Target
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