Stim2 Antikörper (Center)

Produktnummer ABIN500831

Der Kaninchen Polyklonal Anti-Stim2-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, Stim2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für Stim2 Antikörper (Center) (ABIN500831)

Target: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Stim2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Stim2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects STIM2 at center. It is predicted to have no cross-reactivity to STIM1.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: STIM2 antibody was raised against a 17 amino acid peptide from near the center of human STIM2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu Stim2

Target: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Andere Bezeichnung: STIM2

Hintergrund: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.Synonyms: KIAA1482, Stromal interaction molecule 2

Gen-ID: 57620

NCBI Accession: NP_065911

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling