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p107 Antikörper (pThr369) (AbBy Fluor® 680)

Dieses Anti-p107-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von p107 in WB, IF (cc) und IF (p). Geeignet für Human.
Produktnummer ABIN5008121

Kurzübersicht für p107 Antikörper (pThr369) (AbBy Fluor® 680) (ABIN5008121)

Target

Alle p107 (RBL1) Antikörper anzeigen
p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reaktivität

  • 73
  • 18
  • 9
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Wirt

  • 70
  • 3
Kaninchen

Klonalität

  • 71
  • 2
Polyklonal

Konjugat

  • 32
  • 6
  • 5
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser p107 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation

  • 60
  • 34
  • 26
  • 26
  • 11
  • 9
  • 7
  • 6
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 17
    • 15
    • 8
    • 8
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr369

    Kreuzreaktivität

    Human

    Homologie

    Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic phosphopeptide derived from human p107 around the phosphorylation site of Thr369

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

    Andere Bezeichnung

    p107

    Hintergrund

    Synonyms: RBL1phospho T369, 107 kDa retinoblastoma-associated protein, Cellular protein 107, Cellular protein p107, CP107, MGC40006, p107, PRB1, RBL1, RBL1_HUMAN, Retinoblastoma like protein 1, retinoblastoma-like 1 p107, Retinoblastoma-like protein 1.

    Background: p107 is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

    Gen-ID

    5933

    Pathways

    Zellzyklus, Mitotic G1-G1/S Phases
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