Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

RNF168 Antikörper (C-Term)

RNF168 Reaktivität: Human, Maus WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500624
  • Target Alle RNF168 Antikörper anzeigen
    RNF168 (Ring Finger Protein 168 (RNF168))
    Bindungsspezifität
    • 8
    • 8
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 32
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 27
    • 4
    • 2
    Kaninchen
    Klonalität
    • 31
    • 2
    Polyklonal
    Konjugat
    • 19
    • 4
    • 3
    • 3
    • 2
    • 2
    Dieser RNF168 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 20
    • 5
    • 5
    • 2
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects RNF168.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    RNF168 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human RNF168.
    Isotyp
    IgG
    Top Product
    Discover our top product RNF168 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Li, Guan, Huang, Hu, Zheng: "RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair." in: Journal of cell science, Vol. 127, Issue Pt 10, pp. 2238-48, (2014) (PubMed).

  • Target
    RNF168 (Ring Finger Protein 168 (RNF168))
    Andere Bezeichnung
    RNF168 (RNF168 Produkte)
    Synonyme
    3110001H15Rik antikoerper, hRNF168 antikoerper, ring finger protein 168 antikoerper, ring finger protein 168, E3 ubiquitin protein ligase L homeolog antikoerper, Rnf168 antikoerper, rnf168.L antikoerper, RNF168 antikoerper
    Hintergrund
    RNF168 was identified as a chromatin-associated RING finger protein that acts as a ubiquitin ligase both in vitro and in vivo. RNF168 targets histones H2A and H2AX, but not H2B, forming K63 polyubiquitin chains. Upon formation of DNA double strand breaks, RNF168 is recruited to the site of DNA damage where it co-localizes with gammaH2AX and 53BP1 in an RNF8-dependent manner. This localization of RNF168 increases the local concentration of ubiquinated proteins to the threshold required for retention of the proteins 53BP1 and BRCA1, facilitating the downstream signaling cascade. Thus, RNF168 defines a new pathway demonstrating a functional cooperation between E3 ligases in genome maintenance. At least three isoforms of RNF168 are known to exist.Synonyms: E3 ubiquitin-protein ligase RNF168, RING finger protein 168
    Gen-ID
    165918
    NCBI Accession
    NP_689830
    UniProt
    Q8IYW5
    Pathways
    Production of Molecular Mediator of Immune Response
Sie sind hier:
Kundenservice