KDM3B Antikörper (AA 1601-1761) (AbBy Fluor® 750)

Produktnummer ABIN5005670

Dieses Anti-KDM3B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KDM3B in WB, IF (cc) und IF (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für KDM3B Antikörper (AA 1601-1761) (AbBy Fluor® 750) (ABIN5005670)

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM3B Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-KDM3B Antikörper (AbBy Fluor® 750)

Bindungsspezifität: AA 1601-1761

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human JMJD1B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu KDM3B

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Andere Bezeichnung: JMJD1B

Hintergrund:

Synonyms: JHDM2B, JmjC domain containing histone demethylation protein 2B, JmjC domain-containing histone demethylation protein 2B , jmjd1b, Jumonji domain containing protein 1B, JUMONJI DOMAIN-CONTAINING PROTEIN 1B , KDM3B, KDM3B_HUMAN, Lysine-specic demethylase 3B, Nuclear protein 5qNCA.

Background: JMJD1B (jumonji domain containing 1B), also known as KDM3B, 5qNCA (5q Nuclear Co-Activator) or C5orf7, is a member of the JHDM2 histone demethylase family of proteins. Expressed in a wide variety of tissues, JMJD1B localizes to the nucleus and contains one JMJC domain and a C-terminal zinc finger motif. JMJD1B functions as a histone demethylase and, using iron as a cofactor, demethylates lysine-9 of Histone H3. This suggests that JMJD1B plays a central role in the histone code. The gene encoding human JMJD1B is located within the 5q region of the genome that is often deleted in myeloid leukemias and myelodysplasias. This implies that JMJD1B may function as a tumor suppressor of myeloid leukemia. Eptopic expression of JMJD1B exhibits growth suppressive activities, further supporting a role for JMJD1B in tumor suppression.

Gen-ID: 51780

Pathways: Warburg Effekt