PRTFDC1 Antikörper (Center)

Produktnummer ABIN500545

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PRTFDC1 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für PRTFDC1 Antikörper (Center) (ABIN500545)

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRTFDC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-PRTFDC1 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody detects PRTFDC1.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: PRTFDC1 antibody was raised against a 14 amino acid peptide from near the center of human PRTFDC1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu PRTFDC1

Target: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Andere Bezeichnung: PRTFDC1

Hintergrund: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.Synonyms: HHGP, Phosphoribosyltransferase domain-containing protein 1

Gen-ID: 56952

NCBI Accession: NP_064585

UniProt: Q9NRG1

Pathways: Ribonucleoside Biosynthetic Process