PARL Antikörper (N-Term)

Produktnummer ABIN500451

Dieses Anti-PARL-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PARL in WB, IF und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PARL Antikörper (N-Term) (ABIN500451)

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-PARL Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects PARL.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: PARL antibody was raised against a 15 amino acid peptide from near the amino terminus of human PARL.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu PARL

Target: PARL (Presenilin Associated, Rhomboid-Like (PARL))

Andere Bezeichnung: PARL

Hintergrund: PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1, a protein that prevents the release of cytochrome C from the mitochondria in response to apoptotic signals. In lymphocytes and neurons, PARL's association with other proteins, such as the Bcl-2 family-related protein Hax1 and Omi can lead to the proteolytic processing of Omi by PARL, preventing the accumulation of Bax, thereby suppressing apoptosis. Variations in this gene have been associated with increased risk for type 2 diabetes. PARL may also play a role in the progression of Alzheimer's disease through its associations with presenilin-1 and -2. Despite its predicted molecular weight of ~42 kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Multiple isoforms of PARL are known to exist.Synonyms: Mitochondrial intramembrane cleaving protease PARL, PRO2207, PSARL, Presenilins-associated rhomboid-like protein mitochondrial

Gen-ID: 55486

UniProt: Q9H300

Pathways: Autophagie