LSD1 Antikörper (Center)

Produktnummer ABIN500200

Produktdetails anti-LSD1 Antikörper

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LSD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects LSD1 at center.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Peptide affinity chromatography

Immunogen: LSD1 antibody was raised against a 16 amino acid peptide from near the center of human LSD1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu LSD1

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Andere Bezeichnung: AOF2 (KDM1A Produkte)

Synonyme: AOF2 antikoerper, BHC110 antikoerper, KDM1 antikoerper, LSD1 antikoerper, 1810043O07Rik antikoerper, AA408884 antikoerper, Aof2 antikoerper, D4Ertd478e antikoerper, Kdm1 antikoerper, Lsd1 antikoerper, mKIAA0601 antikoerper, DKFZp459N2450 antikoerper, RGD1562975 antikoerper, aof2 antikoerper, kdm1 antikoerper, wu:fb82e06 antikoerper, wu:fc51a02 antikoerper, wu:fj36a05 antikoerper, wu:fj66b06 antikoerper, KDM1A antikoerper, lsd1 antikoerper, xLSD1 antikoerper, AtLSD1 antikoerper, F9F13.30 antikoerper, F9F13_30 antikoerper, LESION SIMULATING DISEASE antikoerper, LESION SIMULATING DISEASE 1 antikoerper, lysine demethylase 1A antikoerper, lysine (K)-specific demethylase 1A antikoerper, lysine (K)-specific demethylase 1a antikoerper, LSD1 zinc finger family protein antikoerper, KDM1A antikoerper, Kdm1a antikoerper, kdm1a antikoerper, LSD1 antikoerper

Hintergrund: Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation (3,4). Experiments have shown that CoREST, a SANT domain-containing corepressor (5) acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein (6), inhibits CoREST/LSD1 activity in vitro (3). LSD1-mediated histone demethylation thus may have significant effects on gene expression.Synonyms: BRAF35-HDAC complex protein BHC110, Flavin-containing amine oxidase domain-containing protein 2, KIAA0601, LSD1, Lysine-specific histone demethylase 1

Gen-ID: 23028

NCBI Accession: NP_055828

UniProt: O60341

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effekt