DNMT3L Antikörper (AA 131-230) (AbBy Fluor® 680)

Produktnummer ABIN5001416

Dieses Anti-DNMT3L-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DNMT3L in WB, IF (cc) und IF (p). Geeignet für Human.

Kurzübersicht für DNMT3L Antikörper (AA 131-230) (AbBy Fluor® 680) (ABIN5001416)

Target: DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT3L Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-DNMT3L Antikörper (AbBy Fluor® 680)

Bindungsspezifität: AA 131-230

Kreuzreaktivität: Human

Homologie: Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Dnmt3L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DNMT3L

Target: DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Andere Bezeichnung: Dnmt3L

Hintergrund:

Synonyms: Cytosine 5 methyltransferase 3 like protein, DNA cytosine 5 methyltransferase 3 like, DNA cytosine-5-methyltransferase 3-like, DNA Cytosine 5 Methyltransferase 3 Like Protein, DNA Methyltransferase 3 Like Protein, DNM3L_HUMAN, Dnmt 3L, Dnmt3l, Human cytosine 5 methyltransferase 3 like protein, MGC1090.

Background: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.

Gen-ID: 29947