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Calpain 2 Antikörper (AA 301-400) (AbBy Fluor® 680)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Calpain 2 in WB, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN4998957

Kurzübersicht für Calpain 2 Antikörper (AA 301-400) (AbBy Fluor® 680) (ABIN4998957)

Target

Alle Calpain 2 (CAPN2) Antikörper anzeigen
Calpain 2 (CAPN2)

Reaktivität

  • 73
  • 44
  • 21
  • 5
  • 2
  • 1
  • 1
Human, Maus

Wirt

  • 71
  • 8
Kaninchen

Klonalität

  • 60
  • 19
Polyklonal

Konjugat

  • 37
  • 6
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Calpain 2 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation

  • 46
  • 27
  • 16
  • 12
  • 12
  • 11
  • 8
  • 6
  • 5
  • 4
  • 4
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 12
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-400

    Kreuzreaktivität

    Human, Maus

    Homologie

    Rat,Dog,Cow,Sheep

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from mouse Calpain 2

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Calpain 2 (CAPN2)

    Andere Bezeichnung

    Calpain 2

    Hintergrund

    Synonyms: Calcium activated neutral proteinase 2, Calcium activated neutral proteinase, CALP80, Calpain 2 m/II large subunit, Calpain 2 catalytic subunit, Calpain 2 large catalytic subunit, Calpain 2 large subunit, Calpain large polypeptide L2, Calpain M type, Calcium-activated neutral proteinase 2, CALP80, Calpain 2, large [catalytic] subunit, Calpain M-type, Calpain-2 catalytic subunit, Calpain-2 large subunit, CAN2_MOUSE, M-calpain, Millimolar-calpain, Calpain2, CANP 2, CANP L2, CANP2, CANPL 2, CANPL2, CANPml, Capa2, CAPN 2, CAPN2, FLJ39928, M calpain, M calpin, M type, mCANP, Millimolar calpain.

    Background: Calpain, and m calpain, also known as Calpain 2, are intracellular, calcium dependent cysteine proteases. Mu calpain has a micromolar sensitivity (thus the mu) as compared to the millimolar calcium sensitivity of m calpain. Both Calpains 1 and 2 are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. The calpains have papain like activity, thus the pain nomenclature. Both Calpain 1 and Calpain 2 are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain 94, ncl2, ncl3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain 4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.

    Gen-ID

    824
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