GLE1 Antikörper (C-Term)

Produktnummer ABIN499892

Der Kaninchen Polyklonal Anti-GLE1-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, GLE1 in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für GLE1 Antikörper (C-Term) (ABIN499892)

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-GLE1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to GLE1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Gle1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Gle1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu GLE1

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Andere Bezeichnung: GLE1 / GLE1L

Hintergrund: The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.Synonyms: GLE1-like protein, Nucleoporin GLE1

Gen-ID: 2733

NCBI Accession: NP_001003722

UniProt: Q53GS7