ECSIT Antikörper (C-Term)

Produktnummer ABIN499780

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ECSIT in WB, EIA und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für ECSIT Antikörper (C-Term) (ABIN499780)

Target: ECSIT

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ECSIT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ECSIT Antikörper

Bindungsspezifität: C-Term

Spezifität: ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT.

Aufreinigung: Ion exchange chromatography

Immunogen: Human ECSIT (C-Terminus) Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu ECSIT

Target: ECSIT

Andere Bezeichnung: ECSIT

Hintergrund: Activation of NF-?B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses (reviewed in 1). Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 (2) to kinases such as IRAK (3) and other intermediates such as TNF receptor associated factor (TRAF)-6 (4). ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway (5). Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis (6), indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.Synonyms: ECSIT homolog (Drosophila), Evolutionarily conserved signaling intermediate in Toll pathway, SITPEC, Signaling intermediate in toll pathway evolutionarily conserved, mitochondrial

Gen-ID: 51295

NCBI Accession: NP_057665

UniProt: Q9BQ95

Pathways: TLR Signalweg, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom