DISP2 Antikörper (C-Term)

Produktnummer ABIN499750

Produktdetails anti-DISP2 Antikörper

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DISP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to Disp2.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Disp2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human Disp2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Disp2 antibody can be used for the detection of Disp2 by Western blot at 1 -2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu DISP2

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Andere Bezeichnung: DISP2 / DISPB (DISP2 Produkte)

Hintergrund: Disp2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the Disp proteins have been implicated in these pathways. Recently, it has been shown that Disp2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased Disp2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by Disp2 mutants. At least two isoforms of Disp2 are known to exist. This Disp2 antibody is predicted to not cross-react with Disp1 or Disp3.Synonyms: KIAA1742, Protein dispatched homolog 2

Gen-ID: 85455

UniProt: A7MBM2

Pathways: Hedgehog Signalweg