B-Cell Linker Antikörper (pTyr189) (AbBy Fluor® 750)

Produktnummer ABIN4997497

Der Kaninchen Polyklonal Anti-B-Cell Linker-Antikörper wurde für WB und IF (p) validiert. Er ist geeignet, B-Cell Linker in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für B-Cell Linker Antikörper (pTyr189) (AbBy Fluor® 750) (ABIN4997497)

Target: B-Cell Linker (BLNK)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser B-Cell Linker Antikörper ist konjugiert mit AbBy Fluor® 750

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-B-Cell Linker Antikörper (AbBy Fluor® 750)

Bindungsspezifität: pTyr189

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human BLNK around the phosphorylation site of Tyr189 [EN(p-Y)IH]

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu B-Cell Linker

Target: B-Cell Linker (BLNK)

Andere Bezeichnung: BLNK

Hintergrund:

Synonyms: BLNK phospho Y491, p-BLNK phospho Y491, B cell adapter containing SH2 domain protein, B cell adapter containing Src homology 2 domain protein, B cell linker, B cell linker protein, B cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell linker protein, BASH, BASH, Bca, Bca, BLNK, BLNK s, BLNK_HUMAN, Cytoplasmic adapter protein, Ly 57, Ly-57, Ly57, Lymphocyte antigen 57, Lymphocyte antigen-57, Lyw 57, Lyw-57, Lyw57, MGC111051, SLP 65, SLP65, SLP-65, Src homology 2 domain containing leukocyte protein of 65 kDa.

Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].

Gen-ID: 29760

Pathways: BCR Signaling