UBQLN4 Antikörper (N-Term)

Produktnummer ABIN499635

Dieses Anti-UBQLN4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von UBQLN4 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für UBQLN4 Antikörper (N-Term) (ABIN499635)

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBQLN4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-UBQLN4 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to CIP75.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: CIP75 antibody was raised against an 18 amino acid peptide near the amino terminus of human CIP75.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CIP75 antibody can be used for detection of CIP75 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Andere Bezeichnung: Ubiquilin-4

Hintergrund: The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.Synonyms: A1Up, Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, C1orf6, CIP75, Connexin43-interacting protein of 75 kDa, UBIN, UBQLN4

Gen-ID: 56893

UniProt: Q9NRR5