UBQLN4 Antikörper (AA 1-50)

Produktnummer ABIN7450868

Produktdetails anti-UBQLN4 Antikörper

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Bindungsspezifität: AA 1-50

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBQLN4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-UBQLN4/CIP75/Ubiquilin 4 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Andere Bezeichnung: UBQLN4/CIP75/Ubiquilin 4 (UBQLN4 Produkte)

Synonyme: a1u antikoerper, cip75 antikoerper, ubin antikoerper, ubiquilin-4 antikoerper, A1U antikoerper, A1Up antikoerper, C1orf6 antikoerper, CIP75 antikoerper, UBIN antikoerper, A1u antikoerper, AI663987 antikoerper, RGD1308273 antikoerper, ubiquilin 4 L homeolog antikoerper, ubiquilin 4 antikoerper, ubqln4.L antikoerper, ubqln4 antikoerper, UBQLN4 antikoerper, Ubqln4 antikoerper

Hintergrund: Background: Ubiquilin-4 (UBQLN4) plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). It mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. UBQLN4 Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). It acts as an adapter protein that recruits UBQLN1 to the autophagy machinery and mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) [taken from NCBI Entrez Gene (Gene ID: 56893)].

Gen-ID: 56893

UniProt: Q9NRR5