CDIP1 Antikörper (Center)

Produktnummer ABIN499607

Der Kaninchen Polyklonal anti-CDIP1 Antikörper wird verwendet zum Nachweis von CDIP1 in Proben von Human und Maus. Er wurde validiert für WB, IF, IHC (p) und EIA.

Kurzübersicht für CDIP1 Antikörper (Center) (ABIN499607)

Target: CDIP1 (LITAF-Like Protein (CDIP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CDIP1 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody reacts to CDIP.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the center of Human CDIP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CDIP antibody can be used for detection of CDIP at 0.25 - 0.5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CDIP1

Target: CDIP1 (LITAF-Like Protein (CDIP1))

Andere Bezeichnung: LITAF-Like Protein

Hintergrund: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.Synonyms: C16orf5, CDIP, Cell death-inducing protein, Transmembrane protein I1

Gen-ID: 29965

NCBI Accession: NP_037531

UniProt: Q9H305