CDIP1 Antikörper (Center)

Produktnummer ABIN499607

Der Kaninchen-Polyklonal Anti-CDIP1-Antikörper wurde für WB, IF, IHC (p) und EIA validiert. Er ist geeignet zum Nachweis von CDIP1 in Proben aus Human und Maus. }

Kurzübersicht für CDIP1 Antikörper (Center) (ABIN499607)

Target: CDIP1 (LITAF-Like Protein (CDIP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDIP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CDIP1 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody reacts to CDIP.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the center of Human CDIP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: CDIP antibody can be used for detection of CDIP at 0.25 - 0.5 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CDIP1

Target: CDIP1 (LITAF-Like Protein (CDIP1))

Andere Bezeichnung: LITAF-Like Protein

Hintergrund: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death, loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.Synonyms: C16orf5, CDIP, Cell death-inducing protein, Transmembrane protein I1

Gen-ID: 29965

NCBI Accession: NP_037531

UniProt: Q9H305