CARD8 Antikörper

Produktnummer ABIN499535

Der Kaninchen Polyklonal Anti-CARD8-Antikörper wurde für WB, IF und EIA validiert. Er ist geeignet, CARD8 in Proben von Human zu detektieren.

Kurzübersicht für CARD8 Antikörper (ABIN499535)

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-CARD8 Antikörper

Spezifität: CARD8 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARD8.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Human CARD8 / Cardinal / TUCAN Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Immunocytochemistry. Western Blot: CARD8 antibody can be used for detection of CARD8 at 2 μg/mL. K562 cell lysate can be used as Positive Control and a band at approximately 45 kDa canbe detected.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Andere Bezeichnung: CARD8 / NDPP1

Hintergrund: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis (1,2), and caspase-1 and its related proteins ICEBERG and pesudo-ICE (3). Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein (2,4), it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappaB activation.Synonyms: Apoptotic protein NDPP-1, CARD-inhibitor of NF-kappa-B-activating ligand, CARDINAL, Caspase recruitment domain-containing protein 8, DACAR, KIAA0955, TUCAN, Tumor up-regulated CARD-containing antagonist of CASP9

Gen-ID: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity