CARD10 Antikörper

Produktnummer ABIN499533

Der Kaninchen Polyklonal anti-CARD10 Antikörper (ABIN499533) detektiert spezifisch CARD10 in WB, IF und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für CARD10 Antikörper (ABIN499533)

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-CARD10 Antikörper

Spezifität: CARD10 antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human CARD10.

Aufreinigung: Immunoaffinity

Immunogen: Murine CARD10 / Caspase recuitment domain family 10 / CARMA3 / Bimp1 Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western BLot: CARD10 antibody can be used for detection of CARD10 at 5 - 10 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CARD10

Target: CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Andere Bezeichnung: CARD10 / CARMA3

Hintergrund: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10 (1). This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (2). CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-kappaB (1,3). CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the IkappaK complex (4), demonstrating its importance in the regulation of NF-kappaB transcription factor activation.Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 10

Gen-ID: 29775

UniProt: F1BA47

Pathways: S100 Proteine