BUB3 Antikörper (C-Term, N-Term)

Produktnummer ABIN499513

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BUB3 in WB, IF und EIA. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für BUB3 Antikörper (C-Term, N-Term) (ABIN499513)

Target: BUB3 (Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast) (BUB3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BUB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-BUB3 Antikörper

Bindungsspezifität: C-Term, N-Term

Spezifität: This antibody reacts to Bub3.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Bub3 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human bub3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Bub3 antibody can be used for detection of bub3 at 0.5 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BUB3

Target: BUB3 (Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast) (BUB3))

Andere Bezeichnung: BUB3

Hintergrund: The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.Synonyms: Mitotic checkpoint protein BUB3

Gen-ID: 9184

UniProt: O43684

Pathways: Maintenance of Protein Location