BRE Antikörper (N-Term)

Produktnummer ABIN499497

Dieses Anti-BRE-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BRE in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für BRE Antikörper (N-Term) (ABIN499497)

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-BRE Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to BRCC45.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: BRCC45 antibody was raised against a 18 amino acid peptide from near the amino terminus of human BRCC45.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: BRCC45 antibody can be used for detection of BRCC45 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BRE

Target: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Andere Bezeichnung: BRE / BRCC45

Hintergrund: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.Synonyms: BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, BRCC45, BRE, Brain and reproductive organ-expressed protein

Gen-ID: 9577

NCBI Accession: NP_004890

UniProt: Q9NXR7

Pathways: Positive Regulation of Response to DNA Damage Stimulus