BIK Antikörper (N-Term)

Produktnummer ABIN499467

Dieses Anti-BIK-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BIK in WB, IF und EIA. Geeignet für Human und Maus.

Kurzübersicht für BIK Antikörper (N-Term) (ABIN499467)

Target: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-BIK Antikörper

Bindungsspezifität: N-Term

Spezifität: This anitbody reacts to BIK.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: BIK antibody was raised against a 15 amino acid peptide from near the amino terminus of human BIK.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: BIK antibody can be used for the detection of BIK ot at 1 - 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BIK

Target: BIK (BCL2-Interacting Killer (Apoptosis-Inducing) (BIK))

Andere Bezeichnung: BIK

Hintergrund: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such protein BIK was recently identified as an endoplasmic reticulum (ER)-residing pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family that stimulates mitochondrial release of cytochrome c following p53 induction of apoptosis. A significant fraction of BIK is found as an ER transmembrane protein, with most of the protein facing the cytosol. Restricting BIK to the ER membrane by replacing the transmembrane region with that of the ER-selective membrane anchor of cytochrome b(5) resulted in a decreased cytochrome c release from mitochondria and a corresponding drop in cell death. Recent evidence suggests that BIK cooperates with NOXA, another BH3-only protein, to somehow enhance the activation of Bax to stimulate the rapid release of cytochrome c from mitochondria.Synonyms: Apoptosis inducer NBK, BIP1, BP4, Bcl-2-interacting killer, NBK

Gen-ID: 638

UniProt: Q13323

Pathways: Positive Regulation of Endopeptidase Activity