BICD2 Antikörper (Center)

Produktnummer ABIN499459

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BICD2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für BICD2 Antikörper (Center) (ABIN499459)

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BICD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-BICD2 Antikörper

Bindungsspezifität: Center

Spezifität: This antibody reacts to BICD2. This BICD2 antibody will not cross-react with BICD1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: BICD2 antibody was raised against a 14 amino acid peptide from near the center of human BICD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: BICD2 antibody can be used for detection of BICD2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BICD2

Target: BICD2 (Bicaudal D Homolog 2 (BICD2))

Andere Bezeichnung: BICD2

Hintergrund: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.Synonyms: Bic-D2, KIAA0699, Protein bicaudal D homolog 2

Gen-ID: 23299

UniProt: Q8TD16

Pathways: Maintenance of Protein Location