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BICD2 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-BICD2-Antikörper wurde für WB und EIA validiert. Er ist geeignet, BICD2 in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN499457

Kurzübersicht für BICD2 Antikörper (C-Term) (ABIN499457)

Target

Alle BICD2 Antikörper anzeigen
BICD2 (Bicaudal D Homolog 2 (BICD2))

Reaktivität

  • 25
  • 4
  • 4
  • 2
  • 2
Human, Maus, Ratte

Wirt

  • 23
  • 2
Kaninchen

Klonalität

  • 23
  • 2
Polyklonal

Konjugat

  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BICD2 Antikörper ist unkonjugiert

Applikation

  • 14
  • 6
  • 6
  • 4
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody reacts to BICD2. It will not cross-react with BICD1.

    Aufreinigung

    Affinity chromatography purified via peptide column

    Immunogen

    BICD2 antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human BICD2.

    Isotyp

    IgG
  • Applikationshinweise

    ELISA. Western Blot: BICD2 antibody can be used for detection of BICD2 at 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C.
  • Target

    BICD2 (Bicaudal D Homolog 2 (BICD2))

    Andere Bezeichnung

    BICD2

    Hintergrund

    BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.Synonyms: Bic-D2, KIAA0699, Protein bicaudal D homolog 2

    Gen-ID

    23299

    UniProt

    Q8TD16

    Pathways

    Maintenance of Protein Location
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