BCL2A1 Antikörper (N-Term)

Produktnummer ABIN499453

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BCL2A1 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für BCL2A1 Antikörper (N-Term) (ABIN499453)

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-BCL2A1 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody reacts to BFL-1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Bfl-1 antibody was raised against a 14 amino acid peptide from near the amino terminus of human Bfl-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: Bfl-1 antibody can be used for the detection of Bfl-1 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Hintergrund: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. Presumably due to post-translational modifications, Bfl-1 is often observed at higher molecular weight in SDS-PAGE than its predicted molecular weight would suggest.Synonyms: BCL2A1, BCL2L5, BFL1, Bcl-2-like protein 5, Bcl-2-related protein A1, GRS, HBPA1, Hemopoietic-specific early response protein, Protein BFL-1

Gen-ID: 597

NCBI Accession: NP_004040

UniProt: Q16548