AP2M1 Antikörper (C-Term)

Produktnummer ABIN499285

Dieses Huhn Polyklonal-Antikörper erkennt spezifisch AP2M1 in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für AP2M1 Antikörper (C-Term) (ABIN499285)

Target: AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))

Reaktivität: Human, Maus, Ratte

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser AP2M1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-AP2M1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to AP2M1.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: AP2M1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human AP2M1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: AP2M1 antibody can be used for detection of AP2M1 at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu AP2M1

Target: AP2M1 (Adaptor-Related Protein Complex 2, mu 1 Subunit (AP2M1))

Hintergrund: The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.Synonyms: AP-2 mu-2 chain, Adaptin-mu2, CLAPM1, Clathrin assembly protein complex 2 medium chain, Clathrin coat assembly protein AP50, Clathrin coat-associated protein AP5, HA2 50 kDa subunit, KIAA0109, Plasma membrane adaptor AP-2 50 kDa protein

Gen-ID: 1173

NCBI Accession: NP_004059

UniProt: Q96CW1

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom