SIGLEC6 Antikörper (Internal Region)

Produktnummer ABIN499145

Der Ziege Polyklonal anti-SIGLEC6 Antikörper wird verwendet zum Nachweis von SIGLEC6 in Proben von Human. Er wurde validiert für WB und EIA.

Kurzübersicht für SIGLEC6 Antikörper (Internal Region) (ABIN499145)

Target: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SIGLEC6 Antikörper

Bindungsspezifität: Internal Region

Sequenz: C-KWMKYGYTSS K

Spezifität: This antibody is expected to recognize all reported isoforms (NP_001236.4, NP_942142.3, NP_942143.3).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_001236.4, NP_942142.3 and NP_942143.3. Genename: SIGLEC6

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.5-1.5 μg/mL. This antibody detects bands at approx. 60 kDa and 30 kDa in HumanPlacenta lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SIGLEC6

Target: SIGLEC6 (Sialic Acid Binding Ig-Like Lectin 6 (SIGLEC6))

Andere Bezeichnung: CD327 / SIGLEC6

Hintergrund: SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.Synonyms: CD33 antigen-like 1, CD33L, CD33L1, CDw327, OB-BP1, OBBP1, Obesity-binding protein 1, Sialic acid-binding Ig-like lectin 6, Siglec-6

Gen-ID: 946

NCBI Accession: NP_001236

UniProt: O43699