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CEP290 Antikörper
CEP290
Reaktivität: Human, Maus
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-CEP290 Antikörper
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Target
Alle CEP290 Antikörper anzeigen
CEP290
(Centrosomal Protein 290kDa (CEP290))
Reaktivität
Alle Reaktivitäten für CEP290 Antikörper
Human, Maus
Wirt
Alle Wirte für CEP290 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für CEP290 Antikörper
Polyklonal
Konjugat
Alle Konjugate für CEP290 Antikörper
Dieser CEP290 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CEP290 Antikörper
Western Blotting (WB)
Spezifität
This antibody detects endogenous levels of CEP290 protein. (region surrounding Phe812)
Kreuzreaktivität (Details)
Species reactivity (tested):Human and Mouse.
Aufreinigung
Affinity Chromatography using epitope-specific immunogen.
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu CEP290
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Target
CEP290
(Centrosomal Protein 290kDa (CEP290))
Andere Bezeichnung
CEP290 (CEP290 Produkte )
Synonyme
ct87 antikoerper, mks4 antikoerper, rd16 antikoerper, bbs14 antikoerper, jbts5 antikoerper, jbts6 antikoerper, lca10 antikoerper, nphp6 antikoerper, slsn6 antikoerper, sh11ag antikoerper, MGC81471 antikoerper, 3h11ag antikoerper, RGD1311640 antikoerper, BC004690 antikoerper, Nphp6 antikoerper, b2b1454Clo antikoerper, b2b1752Clo antikoerper, im:7145703 antikoerper, im:7147820 antikoerper, 3H11Ag antikoerper, BBS14 antikoerper, CT87 antikoerper, JBTS5 antikoerper, LCA10 antikoerper, MKS4 antikoerper, NPHP6 antikoerper, POC3 antikoerper, SLSN6 antikoerper, centrosomal protein 290 antikoerper, centrosomal protein 290 L homeolog antikoerper, centrosomal protein 290kDa antikoerper, CEP290 antikoerper, cep290.L antikoerper, cep290 antikoerper, Cep290 antikoerper
Hintergrund
CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: CT87, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, KIAA0373, NPHP6, Nephrocystin-6, Tumor antigen se2-2, se2-2
Molekulargewicht
approx. 290 kDa
Gen-ID
80184
NCBI Accession
NP_079390
UniProt
O15078
Pathways
cAMP Metabolic Process , M Phase
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