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VCP Antikörper

VCP Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499040
  • Target Alle VCP Antikörper anzeigen
    VCP (Valosin Containing Protein (VCP))
    Reaktivität
    • 92
    • 49
    • 40
    • 14
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 76
    • 19
    • 2
    Kaninchen
    Klonalität
    • 69
    • 28
    Polyklonal
    Konjugat
    • 61
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Dieser VCP Antikörper ist unkonjugiert
    Applikation
    • 64
    • 37
    • 26
    • 21
    • 19
    • 13
    • 12
    • 11
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of VCP protein. (region surrounding Ala346)
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity chromatography
    Reinheit
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product VCP Primärantikörper
  • Applikationshinweise
    Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1,0 mg/mL
    Buffer
    PBS, pH 7.2, 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    VCP (Valosin Containing Protein (VCP))
    Andere Bezeichnung
    TER ATPase / VCP (VCP Produkte)
    Hintergrund
    Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinsons Disease.Synonyms: 15S Mg(2+)-ATPase p97 subunit, Transitional endoplasmic reticulum ATPase, Valosin-containing protein
    Molekulargewicht
    approx. 88 kDa
    Gen-ID
    7415
    NCBI Accession
    NP_009057
    UniProt
    P55072
    Pathways
    ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway
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