H2AFX Antikörper

Produktnummer ABIN498883

Produktdetails anti-H2AFX Antikörper

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H2AFX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: THis antibody detects endogenous levels of Histone H2A.X protein. (region surrounding Glu145)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu H2AFX

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Andere Bezeichnung: Histone H2A.x (H2AFX Produkte)

Synonyme: H2A.X antikoerper, H2A/X antikoerper, H2AX antikoerper, AW228881 antikoerper, H2ax antikoerper, Hist5-2ax antikoerper, gammaH2ax antikoerper, zgc:56329 antikoerper, h2a.x antikoerper, h2a/x antikoerper, h2ax antikoerper, RGD1566119 antikoerper, h2a antikoerper, h2afx antikoerper, H2A histone family member X antikoerper, H2A histone family, member X antikoerper, H2A histone family member X L homeolog antikoerper, histone cluster 1, H2ah antikoerper, histone cluster 2, H2ab S homeolog antikoerper, histone H2AX antikoerper, H2AFX antikoerper, H2afx antikoerper, h2afx antikoerper, h2afx.L antikoerper, HIST1H2AH antikoerper, hist2h2ab.S antikoerper, LOC100522201 antikoerper, LOC100720536 antikoerper

Hintergrund: H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.Synonyms: H2AFX, H2AX, H2a/x

Molekulargewicht: approx. 15 kDa

Gen-ID: 3014

NCBI Accession: NP_002096

UniProt: P16104

Pathways: Telomere Maintenance, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus