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Cortactin Antikörper (pTyr421)
CTTN
Reaktivität: Human, Maus, Ratte
WB, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-Cortactin Antikörper
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Target
Alle Cortactin (CTTN) Antikörper anzeigen
Cortactin (CTTN)
Bindungsspezifität
Alle Epitope für Cortactin Antikörper
pTyr421
Reaktivität
Alle Reaktivitäten für Cortactin Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für Cortactin Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für Cortactin Antikörper
Polyklonal
Konjugat
Alle Konjugate für Cortactin Antikörper
Dieser Cortactin Antikörper ist unkonjugiert
Applikation
Alle Applikationen für Cortactin Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of Cortactin protein only when phosphorylated at Tyr421.
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity Chromatography using epitope-specific immunogen.
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu Cortactin
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Target
Cortactin (CTTN)
Andere Bezeichnung
Cortactin (CTTN Produkte )
Synonyme
EMS1 antikoerper, 1110020L01Rik antikoerper, Ems1 antikoerper, Cttnb antikoerper, CG3637 antikoerper, Dmel\CG3637 antikoerper, cortactin antikoerper, cttn antikoerper, CTTN1 antikoerper, P85.25 antikoerper, Cttn antikoerper, ems1 antikoerper, CTTN antikoerper, cortactin antikoerper, CG3637 gene product from transcript CG3637-RD antikoerper, cortactin S homeolog antikoerper, cortactin L homeolog antikoerper, src substrate cortactin antikoerper, Src substrate cortactin antikoerper, CTTN antikoerper, Cttn antikoerper, Cortactin antikoerper, cttn.S antikoerper, cttn.L antikoerper, cttn antikoerper, CpipJ_CPIJ006351 antikoerper, Bm1_57220 antikoerper, LOC100533277 antikoerper
Hintergrund
Cortactin (also designated Ems-1) is a filamentous Actin (FActin) binding protein. It has also been shown to be a substrate for Src p60. Cortactin contains tandem 37 amino acid repeats at the amino-terminus and an SH3 domain at the carboxy-terminus. The tandem repeats appear to be necessary for F-Actin binding. Tyrosine phosphorylation of Cortactin by Src p60 results in diminished F-Actin binding to Cortactin and reduced F-Actin cross-linking activity. Cortactin has also been shown to be phosphorylated in response to FGF-1. Cortactin exhibits abundant expression in megakaryocytes and platelets, and it may play a role in the maturation of megakaryocytes.Synonyms: Amplaxin, CTTN, EMS1, Oncogene EMS1
Molekulargewicht
approx. 85.0 kDa
Gen-ID
2017
NCBI Accession
NP_005222
UniProt
Q14247
Pathways
MAPK Signalweg
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