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ATP7A Antikörper
ATP7A
Reaktivität: Human, Ratte, Maus
IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-ATP7A Antikörper
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Target
Alle ATP7A Antikörper anzeigen
ATP7A
(ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
Reaktivität
Alle Reaktivitäten für ATP7A Antikörper
Human, Ratte, Maus
Wirt
Alle Wirte für ATP7A Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für ATP7A Antikörper
Polyklonal
Konjugat
Alle Konjugate für ATP7A Antikörper
Dieser ATP7A Antikörper ist unkonjugiert
Applikation
Alle Applikationen für ATP7A Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Spezifität
This antibody detects endogenous levels of ATP7A protein. (region surrounding His640)
Kreuzreaktivität (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human.
Aufreinigung
Affinity chromatography
Reinheit
> 95 % by SDS-PAGE
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Discover our top product ATP7A Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu ATP7A
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Target
ATP7A
(ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
Andere Bezeichnung
ATP7A (ATP7A Produkte )
Synonyme
ATP7A antikoerper, cal antikoerper, wu:fc43e01 antikoerper, zgc:153422 antikoerper, zgc:158633 antikoerper, DDBDRAFT_0218568 antikoerper, DDBDRAFT_0235190 antikoerper, DDB_0218568 antikoerper, DDB_0235190 antikoerper, atpase antikoerper, Atp7a antikoerper, kal antikoerper, atp7a antikoerper, DSMAX antikoerper, MK antikoerper, MNK antikoerper, SMAX3 antikoerper, Blo antikoerper, DXHXS1608e antikoerper, I14 antikoerper, Mo antikoerper, blotchy antikoerper, br antikoerper, brindled antikoerper, mottled antikoerper, Mnk antikoerper, ATPase copper transporting alpha antikoerper, ATPase, Cu++ transporting, alpha polypeptide antikoerper, P-type ATPase antikoerper, ATP synthase subunit a antikoerper, copper-transporting ATPase 1 antikoerper, ATP7A antikoerper, atp7a antikoerper, LOC100049514 antikoerper, Atp7a antikoerper, LOC412379 antikoerper
Hintergrund
The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin.Synonyms: Copper pump 1, Copper-transporting ATPase 1, MC1, MNK, Menkes disease-associated protein
Gen-ID
538
NCBI Accession
NP_000043
UniProt
Q04656
Pathways
Transition Metal Ion Homeostasis , Ribonucleoside Biosynthetic Process
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