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ATP7A Antikörper (AA 42-61) (PerCP)

ATP7A Reaktivität: Human WB, IHC, IP, IF, ICC Wirt: Maus Monoclonal S60-4 PerCP
Produktnummer ABIN2485195
  • Target Alle ATP7A Antikörper anzeigen
    ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
    Bindungsspezifität
    • 15
    • 14
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 42-61
    Reaktivität
    • 50
    • 29
    • 28
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 36
    • 14
    • 1
    • 1
    Maus
    Klonalität
    • 38
    • 14
    Monoklonal
    Konjugat
    • 25
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ATP7A Antikörper ist konjugiert mit PerCP
    Applikation
    • 42
    • 19
    • 14
    • 13
    • 13
    • 13
    • 13
    • 11
    • 7
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~180 kDa in rat brain membrane preparations.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Synthetic peptide amino acids 42-61 (cytoplasmic C-terminus) of human Copper- transporting ATPase1
    Klon
    S60-4
    Isotyp
    IgG2b
    Top Product
    Discover our top product ATP7A Primärantikörper
  • Applikationshinweise
    • WB (1:500)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2485195 was sufficient for detection of Copper-transporting ATPase1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    ATP7A (ATPase, Cu++ Transporting, alpha Polypeptide (ATP7A))
    Andere Bezeichnung
    ATP7A (ATP7A Produkte)
    Synonyme
    ATP7A antikoerper, cal antikoerper, wu:fc43e01 antikoerper, zgc:153422 antikoerper, zgc:158633 antikoerper, DDBDRAFT_0218568 antikoerper, DDBDRAFT_0235190 antikoerper, DDB_0218568 antikoerper, DDB_0235190 antikoerper, atpase antikoerper, Atp7a antikoerper, kal antikoerper, atp7a antikoerper, DSMAX antikoerper, MK antikoerper, MNK antikoerper, SMAX3 antikoerper, Blo antikoerper, DXHXS1608e antikoerper, I14 antikoerper, Mo antikoerper, blotchy antikoerper, br antikoerper, brindled antikoerper, mottled antikoerper, Mnk antikoerper, ATPase copper transporting alpha antikoerper, ATPase, Cu++ transporting, alpha polypeptide antikoerper, P-type ATPase antikoerper, ATP synthase subunit a antikoerper, copper-transporting ATPase 1 antikoerper, ATP7A antikoerper, atp7a antikoerper, LOC100049514 antikoerper, Atp7a antikoerper, LOC412379 antikoerper
    Hintergrund
    The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-trans locating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood. Mutations in the ATP7B gene lead to the autosomal recessive disorder, Wilson disease, characterized by neurological symptoms and hepatic damage.
    Gen-ID
    538
    NCBI Accession
    NP_000043
    UniProt
    Q04656
    Pathways
    Transition Metal Ion Homeostasis, Ribonucleoside Biosynthetic Process
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