FES Antikörper

Produktnummer ABIN498416

Der Kaninchen Polyklonal anti-FES Antikörper wird verwendet zum Nachweis von FES in Proben von Human und Maus. Er wurde validiert für WB und IHC (p).

Kurzübersicht für FES Antikörper (ABIN498416)

Target: FES (Feline Sarcoma Oncogene (FES))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FES Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FES Antikörper

Spezifität: This antibody detects endogenous levels of Fes protein. (region surrounding Lys161)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FES

Target: FES (Feline Sarcoma Oncogene (FES))

Andere Bezeichnung: C-Fes

Hintergrund: FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex.Synonyms: FES, FPS, Proto-oncogene c-Fps, Proto-oncogene tyrosine-protein kinase Fes/Fps

Molekulargewicht: approx. 80 kDa

Gen-ID: 2242

NCBI Accession: NP_001996

UniProt: P07332

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Signaling Events mediated by VEGFR1 and VEGFR2