ATG3 Antikörper (Middle Region)

Produktnummer ABIN497989

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ATG3 in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für ATG3 Antikörper (Middle Region) (ABIN497989)

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-ATG3 Antikörper

Bindungsspezifität: Middle Region

Aufreinigung: Immunoaffinity Chromatography

Immunogen: ATG3 antibody was raised against an 18 amino acid peptide near the center of Human ATG3 (GenBank accession no. NP_071933).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: ATG3 antibody can be used for the detection of ATG3 at 1-2 μg/mL. Positive Control: Mouse Kidney Tissue Lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu ATG3

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Andere Bezeichnung: APG3 / ATG3

Hintergrund: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. It functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.Synonyms: APG3-like, APG3L, Autophagy-related protein 3, Protein PC3-96

Gen-ID: 64422

NCBI Accession: NP_071933

UniProt: Q9NT62

Pathways: Autophagie