Beclin 1 Antikörper (N-Term)

Produktnummer ABIN497971

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Beclin 1 in WB, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Beclin 1 Antikörper (N-Term) (ABIN497971)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Beclin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Beclin 1 Antikörper

Bindungsspezifität: N-Term

Spezifität: Recognizes Beclin-1 (N-term).

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Beclin-1 antibody was raised against a 17 amino acid peptide from near the amino terminus of Human Beclin-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: Beclin-1 antibody can be used for the detection of Beclin-1 at 0.5-1 μg/mL. Positive Control: 293 Cell Lysate. Immunohistochemistry on Paraffin Sections. Positive Control: Rat Brain Tissue.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.

Details zu Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Andere Bezeichnung: Beclin-1

Hintergrund: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (3,4), is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors (5). Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death (6).Synonyms: BECN1, Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197

Gen-ID: 8678

NCBI Accession: NP_003757

UniProt: Q14457

Pathways: Autophagie