ATG12 Antikörper (Middle Region)

Produktnummer ABIN497964

Dieses Anti-ATG12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATG12 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ATG12 Antikörper (Middle Region) (ABIN497964)

Target: ATG12 (Autophagy Related 12 (ATG12))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-ATG12 Antikörper

Bindungsspezifität: Middle Region

Spezifität: Recognizes APG12/ATG12.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse and Rat

Aufreinigung: Affinity Chromatography purified via peptide column

Immunogen: A 15 amino acid peptide from near the center of Human ATG12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. Antibodies should not be exposed to prolonged high temperatures.

Details zu ATG12

Target: ATG12 (Autophagy Related 12 (ATG12))

Andere Bezeichnung: ATG12 / APG12

Hintergrund: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5, this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.Synonyms: APG12-like, APG12L, Autophagy-related protein 12, Ubiquitin-like protein ATG12

Gen-ID: 9140

NCBI Accession: NP_004698

UniProt: O94817

Pathways: Autophagie