SUV39H2 Antikörper (AA 93-122)

Produktnummer ABIN3029055

Der Kaninchen Polyklonal anti-SUV39H2 Antikörper (ABIN3029055) detektiert spezifisch SUV39H2 in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für SUV39H2 Antikörper (AA 93-122) (ABIN3029055)

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUV39H2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SUV39H2 Antikörper

Bindungsspezifität: AA 93-122

Verwendungszweck: SUV39H2 Antibody (KMT1B)

Aufreinigung: Purified

Immunogen: A portion of amino acids 93-122 from the human protein was used as the immunogen for this KMT1B / SUV39H2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the SUV39H2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu SUV39H2

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Andere Bezeichnung: SUV39H2

Hintergrund: The murine gene Suv39h2/kmt1b encodes an H3 histone methyltransferase (HMTase) 59 % identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

UniProt: Q9H5I1