SMAD2 Antikörper (AA 97-125)
Kurzübersicht für SMAD2 Antikörper (AA 97-125) (ABIN3032613)
Target
Alle SMAD2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 97-125
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Kreuzreaktivität (Details)
- Expected species reactivity: Rat, Bovine, Pig, Chicken, Zebrafish, Drosophila
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Aufreinigung
- Antigen affinity purified
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Immunogen
- A portion of amino acids 97-125 from the human protein was used as the immunogen for this SMAD2 antibody.
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Isotyp
- Ig Fraction
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anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 181-280) antibody
SMAD2 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 3G9 unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 2-467) antibodySMAD2 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (pSer423), (pSer425), (pSer465), (pSer467) antibodySMAD2 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (C-Term) antibodySMAD2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 181-280) antibodySMAD2 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 4D10 unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (pSer467) antibodySMAD2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (N-Term) antibodySMAD2 Reaktivität: Human, Maus, Ratte WB, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (pThr183), (pThr221) antibodySMAD2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 181-280) antibodySMAD2 Reaktivität: Human WB, ELISA, PLA Wirt: Maus Monoclonal 2D7 unconjugated
anti-SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 27-172) antibodySMAD2 Reaktivität: Human, Maus, Ratte WB, IHC, IF, IP Wirt: Maus Monoclonal 48-MAD2 unconjugated
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Applikationshinweise
- Titration of the SMAD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:100,Western blot: 1:1000,Flow Cytometry: 1:10-1:50
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot the SMAD2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
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Andere Bezeichnung
- SMAD2
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Hintergrund
- Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]
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UniProt
- Q15796
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Pathways
- Zellzyklus, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
Target
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