RUNX1 Antikörper (C-Term)

Produktnummer ABIN3032498

Der Kaninchen Polyklonal anti-RUNX1 Antikörper wird verwendet zum Nachweis von RUNX1 in Proben von Human und Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für RUNX1 Antikörper (C-Term) (ABIN3032498)

Target: RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUNX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-RUNX1 Antikörper

Bindungsspezifität: AA 426-459, C-Term

Verwendungszweck: Runx1 Antibody

Aufreinigung: Antigen affinity

Immunogen: This Runx1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 426-459 amino acids from the C-terminal region of mouse Runx1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the Runx1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Runx1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu RUNX1

Target: RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))

Andere Bezeichnung: Runx1

Hintergrund: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematopoiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B- dependent transcriptional activation (By similarity).

UniProt: Q03347